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Therefore, as a rate-limiting enzyme in the synthesis of glutathione (GSH), BSO can inhibit the synthesis of reduced glutathione, reduce the activity of GPX4, and promote ferroptosis [167,168,169,170]

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Open Cardiovasc Med J (2011) 5:7684

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Nat Rev Cancer 22:381396 Leidal AM, Levine B, Debnath J (2018) Autophagy and the cell biology of age-related disease

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