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The tumor suppressor protein p53 increases the expression of the aspartate/glutamate transporter SLC1A3 and the arginine transporter SLC7A3 upon glutamine depletion, leading to resistance to treatments that deplete extracellular glutamine 114,115

The combination might successfully minimize renal damage of A on C patients, enhance restoration of kidney functionality, and relieve clinical symptoms in these individuals

MOTS-c enhanced glycolytic flux and energy production in muscles affected Duchenne muscular dystrophy (DMD), in addition to improving muscle capacity in healthy mice [93]

High-dose antioxidant supplements carry risks including drug interactions (vitamin E with warfarin), increased bleeding, and potential harm shown in some clinical studies

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Glutamate-cysteine ligase (GCL) Combines glutamate and cysteine to form gamma-glutamylcysteine