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--- The Clinical Frontier The strongest human evidence now supports: Metformin (metabolic reprogramming) NAD boosters (mitochondrial repair) MSC infusions & TPE (cellular rejuvenation) GLP-1 agonists (metabolic efficiency) The future lies in combination strategies integrating metabolism, cellular repair, and mitochondrial support for multimodal rejuvenation

GSH has key roles in the body: Protects cells, especially mitochondria, from damage by harmful molecules like ROS and inflammation

Glutathione Backs cellular defense and detox balance

The increased malonyl-CoA results in inhibition of fatty acid transport into the mitochondria resulting in reduced fat oxidation and reduced production of excess acetyl-CoA

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[Google Scholar] 46.Parameswaran GI, Murphy TF