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[DOI] [PubMed] [Google Scholar] 110.McKenna MC, Ferreira GC

AMPK, through the inhibition of ACC1 and ACC2, inhibits fatty acid synthesis thereby inhibiting the consumption of NADPH, while elevating fatty acid oxidation to increase the generation of NADPH by malic enzyme (ME) and Isocitrate-dehydrogenase 1 (IDH1) In the absence of this compensation mechanism, which is induced by AMPK, tumor cells may die during solid tumor formation

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