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Regarding the few pathways where the result seems incongruous, when analyzing their topology, it is clear that their activation by B12 is potentially beneficial to the patient

The 3-month on, 2-month off structure preserves that sensitivity and allows natural GH secretion rhythms to reassert themselves during the rest phase
The analogues are dangerous because they can block your B12 receptors and prevent the real B12 from being absorbed
This is another issue of concern with long-term use of melanocortin agonists [60,61]

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