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Similarly, although hepatic dysfunction can occur with large niacin doses (1-3 grams daily over months) causing elevated liver enzymes or jaundice, niacinamide at 100 mg is very unlikely to have any adverse effect on the liver
Baar et al, Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging
Nutrient deficiency leads to multiple health problems such as weakened immune systems, skin problems, indigestion, heart disorders, eye issues, and defective bone development
Perez JL, Khatri L, Chang C, Srivastava S, Osten P, Ziff EB (2001)

It is important to discuss these with your doctor
The shots usually don't hurt, but some people have a slight stinging sensation
