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Conversely, decreased GH/IGF-1 signaling has also been shown to extend longevity in a wide variety of species such as worms, fruit flies, mice, and yeast (468), thus raising the question of whether decreased activity of the GH/IGF-1 axis might be beneficial for human longevity

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Vasoactive Intestinal Peptide (VIP) exerts its effects by binding to specific receptors, VPAC1 and VPAC2, which are widely expressed in various tissues

[DOI] [PubMed] [Google Scholar] 174.Suren P., Roth C., Bresnahan M., Haugen M., Hornig M., Hirtz D., Lie K.K., Lipkin W.I., Magnus P., Reichborn-Kjennerud T., et al

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Peleg AY, Weerarathna T, McCarthy JS, Davis TME