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Because human cells cannot store any significant amount of folate but the liver can store 3-6 years worth of B12, folate deficient megaloblastic anemias manifest very quickly, whereas B12 deficient anemias take considerably longer to manifest

Answers to these questions will provide novel insights into the mechanisms of ferroptotic cell death and associated human diseases, as well as new therapeutic strategies for CVDs treatment

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Virchows Arch 448: 337343, 2006

Idebenone delays the onset of cardiac functional alteration without correction of Fe-S enzymes deficit in a mouse model for Friedreich ataxia

doi: 10.1002/advs.202201734 213 ZhangZLiXWangYWeiYWeiX