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Preclinical studies have shown that several dual IGF-1R/IR RTKi, including OSI-906 (linsitinib) [159], BMS-554417 [148], and BMS-754807 [160,161], exhibit anti-proliferative and pro-apoptotic affects in breast tumor cells, and inhibit breast tumor growth in vivo when given alone or in combination with hormone therapy

Planta Med 84:3441 Nan W, Zhonghang X, Keyan C, Tongtong L, Wanshu G, Zhongxin X (2018) Epigallocatechin-3-gallate reduces neuronal apoptosis in rats after middle cerebral artery occlusion injury via PI3K/AKT/eNOS signaling pathway

The progressive drying and keratinization of the conjunctiva, particularly on the nasal and temporal conjunctiva, results in the development of irregularly shaped spots termed Bitot (bee toe) spots after the French physician, Pierre Bitot, who first described them

Of note, GPX4 deficient mice are not viable and die at embryonic day 8 [3, 4]

Osteopontin is another molecule that has been identified in NVU studies