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Between 14 and 26 minutes the gradient increased to 95% of B and remained at 95% B for 4 min

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major targets is presented in Tables 1 and 2, the list of 254 FDA-approved drugs (henceforth referred to as 'Lm254') is presented in Additional file 1: Table S2, and the list of all drugs associated with the 8 synthetic lethal targets is presented in Additional file 1: Table S3

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Non-covalent inhibitors of thioredoxin glutathione reductase with schistosomicidal activity in vivo

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Breakthroughs in future therapies will largely depend on our ability to more precisely dissect and strategically manipulate this central pathway, ultimately directing powerful offensive capabilities of the immune system against tumors with improved persistence, specificity, and efficacy

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6-benzothiazolyl ureas, thioureas and guanidines are potent inhibitors of ABAD/17-HSD10 and potential drugs for Alzheimers disease treatment: Design, synthesis and in vitro evaluation

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394,395 As mentioned above, HSF1 is subject to numerous PTMs that govern its activation or inhibition at different levels, and the mediators of these PTMs themselves, or their upstream receptors or sensors, help integrate multiple different stimuli in the HSF1-mediated response

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