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Annu Rev Biochem 74:739789

Nuclear genomic instability and aging

Key findings from receptor studies [2] : Long-term studies in -AR knockout mice showed no body weight reduction or lipolysis increases This verified the receptor pathways importance for sustained metabolic effects Acute experiments showed AOD9604 increased energy expenditure even in knockout mice Results suggest -AR expression enhances sensitivity but additional mechanisms exist beyond the direct receptor activation cAMP-PKA-HSL Pathway Activation The peptide triggers increases in intracellular cyclic AMP (cAMP) within adipocytes

MIR-206 , a skeletal muscle-specific microRNA, is a key regulator in skeletal muscle development

Sirtuin 1 (SIRT1) prevents inflammatory responses in articular chondrocytes, and resveratrol, a natural SIRT1 activator, can exert a protective effect on chondrocytes by inhibiting NF-B and MMP-13 expression (126)

doi: 10.1096/fj.202000564R 86 HendersonJDuffyLStrattonRFordDO'ReillyS
