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Annu Rev Biochem 74:739789

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Nuclear genomic instability and aging

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Key findings from receptor studies [2] : Long-term studies in -AR knockout mice showed no body weight reduction or lipolysis increases This verified the receptor pathways importance for sustained metabolic effects Acute experiments showed AOD9604 increased energy expenditure even in knockout mice Results suggest -AR expression enhances sensitivity but additional mechanisms exist beyond the direct receptor activation cAMP-PKA-HSL Pathway Activation The peptide triggers increases in intracellular cyclic AMP (cAMP) within adipocytes

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MIR-206 , a skeletal muscle-specific microRNA, is a key regulator in skeletal muscle development

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Sirtuin 1 (SIRT1) prevents inflammatory responses in articular chondrocytes, and resveratrol, a natural SIRT1 activator, can exert a protective effect on chondrocytes by inhibiting NF-B and MMP-13 expression (126)

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doi: 10.1096/fj.202000564R 86 HendersonJDuffyLStrattonRFordDO'ReillyS

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