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Inefficient metabolism has been shown to lead to the accumulation of metabolic intermediates that can interfere with mitochondrial function and impair the ability to produce ATP

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EFSA J 12(5):3660 Leung AM, Avram AM, Brenner AV, Duntas LH, Ehrenkranz J, Hennessey JV et al (2015) Potential risks of excess iodine ingestion and exposure: statement by the american thyroid association public health committee

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Neuroprotective activity of acetyl-L-carnitine: studies in vitro J Neurosci Res 1994

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Also, vitamin A levels have been found to be significantly lower in the skin (Rollman 1985) and plasma (Labadarios 1987) of acne patients compared to acne-free controls

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