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The Lavis group made a seminal discovery that substituting the dialkylamino group with an azetidine group is a general method to significantly improve quantum yields of fluorophores 17

doi: 10.1016/j.ijmm.2007.03.002 179 PuigC.MartiS.FleitesA.TrabazoR.CalatayudL.LinaresJ.et al

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Both routes deliver comparable bioavailability SubQ achieves 8592% versus IMs 8894%, a clinically insignificant 34% difference

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