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Mice that lack an organised synovial lining layer due to the deficiency of cadherin-11 are indeed resistant to the development of arthritis, demonstrating a causal role of fibroblasts in the disease ( + THY1 + cells are mainly mediators of inflammation, the destruction of joint tissues is mostly mediated by FAP + THY1 - fibroblasts ( The driving role of fibroblasts in cancer is also well studied

Another major route of cholesterol delivery to the liver is mediated through LDL and the LDL receptor (LDLR) (Figure 6) (701)

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Prior to the procedure local anesthesia is applied to make patients more comfortable