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Severe Symptoms In the most serious cases, GBS can lead to life-threatening complications: Difficulty Breathing : As the muscles involved in breathing are affected, individuals may experience shortness of breath or require mechanical ventilation

Epigenetics as a mechanism of gene expression regulation in cancer Epigenetics encompasses reversible modifications to gene expression without changes in the DNA sequence itself (Cheng et al

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Liver Int 34(3):367378 Trauner M, Claudel T, Fickert P, Moustafa T, Wagner M (2010) Bile acids as regulators of hepatic lipid and glucose metabolism

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In conclusion, glutamine antimetabolites effectively inhibit tumor growth while improving the anti-tumor immune response through multiple mechanisms, revealing the close interaction between glutamine metabolism and immune response in the TME (Fig