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The mice are placed at the end of any arm of the Y-maze and allowed to explore freely

62,63 Excess iron is stored in unstable iron pools, which can increase due to metabolic imbalance, leading to increased ROS production through Fenton reactions

As a result, adverse drug reactions or therapy failure may occur

We subsequently performed gene set enrichment analysis (KEGG) on these intersecting genes and ultimately identified a metabolic pathway that was closely associated with GSH metabolism and selenide metabolism (Figure 5C)

GSH depletion and concomitant increase in O&NS and mitochondrial dysfunctions play a role in the pathophysiology of diverse neuroimmune disorders, including depression, myalgic encephalomyelitis/chronic fatigue syndrome and Parkinsons disease, suggesting that depleted GSH is an integral part of these diseases

PMCID: PMC6995950