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Activation of UCP1, a proton channel in the inner mitochondrial membrane of brown adipocytes, produces a leak in the mitochondrial membrane and uncouples ATP synthesis from respiration, thereby dissipating energy as heat (6, 100)

The compound triggers a process the downstream benefits depend on how much senescent cell burden existed, how efficiently the immune system clears debris, and how effectively tissues regenerate
[DOI] [PMC free article] [PubMed] [Google Scholar] 293.Upton JW, Kaiser WJ, Mocarski ES

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