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This represents approximately 3-fold improved local delivery and demonstrates that formulation significantly impacts outcomes

It is true that B12 levels will be depleted by alcohol - the reduction is small with a single drink but probably worse if you go over that

Recent studies on Long COVID and ME/CFS patients have revealed signs of elevated oxidative stress and aberrations in ROS clearance pathways, including elevated glutathione levels, decreases in mitochondrial superoxide dismutase, and lipid oxidative damage

B12 is an essential vitamin that the body needs to function properly

this relationship seems to play a relatively minor role, as far as current research shows

Moreover, the microtubule stabilization, remyelination and myelin reparation were rescued by vitamin B 12 , which was consistent with the treatment of 4-phenylbutyric acid (4-PBA), an endoplasmic reticulum stress inhibitor