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Lysosomal accumulation was observed in SMCR8 deficient macrophages from Smcr8 /mice , possibly because of increased ROS (Mcalpine et al., 2018)

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[DOI] [PubMed] [Google Scholar] 101.Rosenfeldt F., Hilton D., Pepe S., Krum H

Even when tested for metabolic competency, the differences in the gene expression profiles compared to primary hepatocytes always raise concerns regarding the applicability of the investigated intracellular signaling mechanisms and the mode of cell death in humans

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