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As a topical treatment, systemic exposure is minimal

The role of basolateral amygdala and medial prefrontal cortex in fear: a systematic review

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whilst alcohol swabs are not always necessary for patients with good hygiene, they may be used if preferred

While the peptide itself has a short half-life and doesnt build up, the cellular changes it initiates benefit from uninterrupted signaling

And several peptides were designed or have been shown to work exactly at those levels
