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As an adjunctive treatment to standard of care, it demonstrated cardioprotective and renoprotective properties in a mandatory cardiovascular outcome trial that was largely independent of glycemic control in patients with established cardiovascular disease and T2DM

Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts

Modulation of Smad2-mediated signaling by extracellular signal-regulated kinase

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10.3390/ijms17122069 Int J Mol Sci
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