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Scoparone Scoparone has been found to promisingly ameliorate the pathological alterations and prevent the development of HCC from nonalcoholic fatty liver disease (NAFLD) in a NAFLD-HCC mouse model by modulating p38 MAPK/Akt/NF-B signaling cascade, with deactivation of MAPK/Akt pathway and downregulation of NF-B, TNF-, monocyte chemoattractant protein-1 (MCP-1), iNOS, COX-2, and MMP9 expressions [275]

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