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Abbreviations GSH: Glutathione BSO: L-buthionine-sulfoximine ROS: Reactive oxygen species GST: Glutathione S-transferase DEM: Diethyl maleate ITCs: Isothiocyanates GCL: Glutamate-cysteine ligase GPX: Glutamate peroxidases Fmoc: 9-Fluorenylmethyloxycarbonyl TOFMS: Time-of-flight mass spectrometry TEM: Transmission electron microscopy NPs: Nanoparticles PBS: Phosphate buffered saline HPLC: High-performance liquid chromatography LCMS: Liquid chromatography-mass spectrometry IC 50 : Half-maximal inhibitory concentration CLSM: Confocal laser scanning microscopy RhoB: Rhodamine B Fer-1: Ferrostatin-1 t-BuOOH: Tert-butylhydroperoxide DCFH-DA: 2,7-Dichlorodihydrofluorescein diacetate LDH: Lactate dehydrogenase ATP: Adenosine triphosphate GSDMD: Gasdermin D GSDME: Gasdermin E References Mo R, Gu Z

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