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In addition to dedifferentiation, another consequence of in vitro expansion is replicative senescence, which also significantly influences chondrocyte function
They aren't even distant cousins in the sprawling family of signaling molecules

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This action promotes the firing of layer V pyramidal neurons and stimulates glutamate release ( 5.1.2 Impact on neurotransmitters and synaptic plasticity Chronic ketamine use disrupts the balance between excitatory and inhibitory neurotransmission

If folate deficiency is present, replacement should only be started after initiating B12 therapy to avoid worsening neurological symptoms

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