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A significantly greater percentage of those with higher EDSS scores experienced moderate to severe feelings of pessimism (18.7% vs 11.8%, P = .026) and lower life satisfaction (8.8% vs 3.6%, P = .016) when compared with those with stable EDSS scores

This is especially evident in individuals with pernicious anemia, a decrease in B12 absorption that additionally heightens stomach cancer risk

High mutational concordance between primary colorectal tumors and associated pulmonary metastases

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However, severe renal impairment and end stage renal disease lack sufficient safety data

Stool color changes can happen due to recent dietary shifts and are generally not of concern unless they stay continuous over long periods of time or accompanied with unusual pain, cramping, fever, diarrhea or vomiting