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Similarly, abnormal aggregated proteins such as -synuclein (-SYN) cannot be cleared or transported in time due to abnormal BBB function, and then deposit in the brain, exerting toxic effects on nerve cells and promoting the progression of the PD (Wang H

Decreased d-serine levels prevent retinal ganglio cell apoptosis in glaucomatous animal model

Exposure of astrocytes to various -amyloid peptides, and -amyloid 2535 in particular, increased Cx43 expression and appears to redistribute connexins from gap junction assemblies to hemichannels 486,488,489 , the latter, in turn, mediating excessive release of glutamate and ATP resulting in excitotoxicity 489,490,491

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[DOI] [PMC free article] [PubMed] [Google Scholar] Arnold F

For leukoplakia, curcumin functions as an antioxidant by inhibiting ROS production, elevating salivary levels of vitamins C and D, protecting against lipid peroxidation and DNA damage, regulating cell proliferation, inhibiting nuclear factor-kappa B (NF-B), and preventing invasion and metastasis in the epithelium by suppressing excessive TGF receptor signaling (Rai et al., 2010