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Extensive lung transcriptome analysis established that individuals with high risk factors for severe disease outcomes expressed ACE2 at much greater levels than control subjects 19

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Furthermore, it was reported that TAU significantly suppresses the cell proliferation induced by the platelet-derived growth factor (PDGF)-BB via the protein tyrosine phosphatase (PTPase)-mediated suppression of the PDGF- receptor phosphorylation and by decreasing the activation of its downstream signaling molecules in VSMCs 37

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