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Even though initial works have shown that some antioxidant enzymes present a greater activity in cells from AD patients (Zemlan et al., 1989), it has recently been shown that many antioxidant enzymes, such as SOD2, catalase and glutathione peroxidase, present lower activities in AD (Marcus et al., 1998

Acid sphingomyelinase mediates ferroptosis induced by high glucose via autophagic degradation of GPX4 in type 2 diabetic osteoporosis

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doi: 10.1016/j.exphem.2013.12.001