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Further, a secondary analysis of a trial in women at high risk for or with existing cardiovascular disease reported that high-dose supplemental B-vitamins (1 mg/day of vitamin B 12 , 50 mg/day of vitamin B6, and 2.5 mg/day of folic acid) for 7.3 years had no effect on risk of non-vertebral fractures (122)

Summary More efficient oral and injectable forms may cause B12 overload

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If weight loss is the primary goal, B12 is, at best, a supporting piece of a larger plan rather than the plan itself