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On the basis of this finding the authors suggested the pathway shown in Figure 3A, according to which glucose-derived -ketoglutarate leaves the astrocytic TCA cycle in exchange with malate, generated via oxaloacetate (OAA), which in turn had been formed from aspartate in a transamination process

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[PubMed] [Google Scholar] 3.Newman A, Clutterbuck RD, Powles RL, Catovsky D & Millar JL A Comparison of the Effect of the 3-Hydroxy-3-Methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitors Simvastatin, Lovastatin and Pravastatin on Leukaemic and Normal Bone Marrow Progenitors

It does not address issues such as toxic chemicals, heavy metals, radioactive materials and more
