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While shorter wavelengths, such as 351 nm are better at absorbing melanin, longer wavelengths penetrate deeper into the skin, increasing their ability to reach deeper melanosomes (Fig

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31,35 In contrast, our results revealed that CPT1A-mediated FAO was a crucial metabolic characteristic of LCSCs, and the suppression of CPT1A promoted ferroptosis sensitivity but not apoptosis in LCSCs

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No tolerance development to the lipolytic effects was noted in these studies, suggesting that unlike beta-2 agonists (which rapidly desensitize their receptors), beta-3 receptor activation may not produce the same downregulation pattern