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Neurological deficits and developmental delays commonly occur in the early years of life, are noticed as intellectual disabilities and may progress to repeated seizures (17)

The treatment difference of 17.3 percentage points versus placebo represents the largest weight reduction achieved by any pharmacotherapy in a Phase 3 trial
doi: 10.1053/jhep.2003.50423

The chemotherapy drug, 5-fluorouracil (5-fu), inhibits TS activity by disrupting action of TS, causing DNA and RNA damage, making 5-fu an effective and commonly used cancer treatment [74]

Guanidinoacetate N -methyltransferase is encoded by the GAMT gene
