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Systematic screening of generic drugs for progressive multiple sclerosis identifies clomipramine as a promising therapeutic

( MAT2A expression in Jurkat and MOLT-4 CD4+ T cells, which leads to decreased SAM levels and increased T cell activation-induced apoptosis

Ann N Y Acad Sci (2017) 1397:13042

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Bilirubin interacted directly with mitochondria, affecting membrane lipid and protein characteristics, redox status, and cytochrome C concentration, and bilirubin-induced apoptosis may be mediated in part by physical changes in the mitochondrial membrane