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We investigated the etiopathogenetic role ofmanganesesuperoxidedismutase(MnSOD) (Ala-9Val) andglutathioneperoxidase(GSH-Px) (Pro197Leu)genepolymorphismsin patients diagnosed with major depressive disorder (MDD) and bipolar I disorder (BD)

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Furthermore, it highlights the role of NAD+ in mitochondrial homeostasis in aging and disease conditions, the latest results of NAD+-boosting therapeutics in clinical trials, and areas of further translational development.