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10.1021/acs.jcim.2c01057 135 KrysiakK.DanosA

DIRECT STRUCTURAL LINKS BETWEEN IRON AND -SYN CONFORMATION Iron deposition has been shown to promote -syn aggregation both in vitro and in vivo , although the exact structural basis and underlying mechanisms remain unknown

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During glutamoptosis, mTORC1-mediated inhibition of autophagy leads to the accumulation of the autophagic cargo protein sequestosome1/p62 (SQSTM1/p62)