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IDH1/2 use NADP + as a cofactor and conduct a reversible reaction, while IDH3 uses NAD + as a cofactor and conducts irreversible conversion

Hydrogen nutrition therapy application in obesity and metabolic disorders The excessive production of free radicals can induce discontinuation of the gastrointestinal tract barrier, thereby causing the inflammation and the loss of redox homeostasis observed in some gastrointestinal diseases and implicated in the pathogenesis of several gastrointestinal disorders [2]

A., Abd El Latif A., Okanda T., Kato Y., et al

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