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This review synthesizes mechanistic insights from redox biology and immunometabolism to clinical trial data, proposing a framework for optimizing VC-based combination therapies while addressing critical gaps in biomarker development and dose scheduling

The bone microenvironment is important for maintaining normal bone physiology and regulating it in pathological settings

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They ingested increasing doses of niacin (250-1000 mg daily) for 16 weeks as described previously 15 , and the blood samples were taken in different timepoints during the supplementation

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