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Adjuvant Regimen Overview by Cancer Type Breast Cancer Adjuvant therapy selection in breast cancer is driven by tumor biology (hormone receptor status, HER2 status, tumor grade) and genomic testing (Oncotype DX recurrence score) per NCCN Breast Cancer Guidelines: AC-T (doxorubicin + cyclophosphamide, followed by paclitaxel): Standard adjuvant regimen for HR-negative or high-risk HR+ breast cancer

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