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Growth-inhibitory effect of a novel synthetic triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, on ovarian carcinoma cell lines not dependent on peroxisome proliferator-activated receptor-gamma expression

Moreover, inflammatory factors activate signaling pathways within endothelial cells, such as the nuclear factor-B (NF-B) pathway, further upregulating the expression of adhesion molecules (such as ICAM-1 and VCAM-1), which facilitates leukocyte adhesion and transmigration across the endothelium, thereby exacerbating BSCB damage

Slides were stained automatically using a Leica Bond system (Leica Biosystems)

The duration of supplementation ranged from three to nine months, with outcomes evaluated at defined intervals of three, six, or nine months

Larkin MA, Blackshields G, Brown NP, Chenna R, McGettigan PA, McWilliam H, et al