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Chronic oxidative stress compromises telomere integrity, accelerating the onset of senescence in human endothelial cells (Kurz et al., 2004)

Black or tarry stool, visible blood in the stool, vomiting blood, severe abdominal pain, unexplained weight loss, persistent fever, anemia, or progressive swallowing difficulty should be evaluated appropriately

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As drug development programs are fast approaching US$3 billion per FDA-approved drug, the consideration of a prodrug strategy early in development may be more efficient than attempting to save a problematic candidate later in the pipeline [6]

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