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Interestingly, in isolated islets, bilirubin suppresses ferroptosis and ferroptosis-related characteristics, thus leading to reduced oxidative stress, elevated GPX4 expression, upregulated nuclear factor erythroid 2-related factor 2NRF2/heme oxygenase-1, and decreased iron levels [112]

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This complicates and broadens the picture, but on the other hand, it may require researchers to find new factors to consider in the exclusion and inclusion criteria for clinical trials

Biochem Biophys Res Commun 439(1):103108

Brain tissue is also rich in polyunsaturated lipids that can be damaged by oxidation

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