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however, its future use is expected to become extremely limited due to concerns about human health and environmental pollution

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J Med Chem 50:50535056 Shyama S, Robert A, Ying S, Sonoko N, Brock B, Jos Luis M, Eduard S, Nicholas DPC (2009) Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP)