glutathione cell uptake Glutathione/pH-responsive copper-based nanoplatform for amplified chemodynamic therapy through synergistic cycling regeneration of reactive oxygen species and dual depletion Dysregulated glutathione metabolism impairs natural

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(57) found that zero-valent iron (ZVI), a nanoparticle capable of inducing ferroptosis in tumor cells, was able to convert M2 type TAM into M1 type, lifting the inhibition of anti-tumor immunity

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Future studies should prioritize (1) isolating and characterizing the active compounds within these botanicals, (2) elucidating their precise molecular targets (e.g., thyroid peroxidase, sodium-iodide symporter, cytokine signaling pathways), and (3) conducting well-designed controlled clinical trials to rigorously evaluate their safety and efficacy in human patients