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202 In another study, a combination of vitamin C (100 mg) and vitamin E (400 IU), taken by mouth twice daily for 45 days, led to reductions in the frequency of apneic episodes and daytime sleepiness and improved sleep quality in 20 men with obstructive sleep apnea being treated with CPAP

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A single unusual case report did describe a life-threatening eosinophilic pneumopericardium effusion (a type of fluid accumulation around the lungs and heart with high eosinophil counts) in an elderly woman who had been concurrently taking high-dose pantothenic acid (vitamin B5 at 300 mg/day) and biotin (10 mg/day) for two months

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