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MOMP-dependent release of dsRNA induces a type I interferon response Detection of pathogenic or mitochondrial dsRNA in the cytosol is enabled by retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) receptors which subsequently mediate the accumulation of MAVS on the mitochondrial outer membrane [70]

Additionally, FPIinduced epileptic rats displayed behavioral changes, such as pauses, facial automatisms, and myoclonus, during epileptiform events, thereby validating the utility of the FPI model as a valuable tool for studying the underlying mechanisms of spontaneous epileptogenesis [234]

Currently, there are several therapies emerging and undergoing trials in animal models that focus on the manipulation and administration of several growth factors implicated in the healing process (Halper 2014