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These systems form a continuous design-build-test-learn cycle that enables the rapid and autonomous iteration of small-molecule immunotherapeutic candidates, drastically reducing development timelines and improving hit quality

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Additionally, microglia, the brains resident immune cells, exhibit a metabolic flexibility that allows them to shift between oxidative phosphorylation and glycolysis, depending on their activation state, which significantly influences neuroinflammation and synaptic plasticity

(2009) Plasma polyunsaturated fatty acids and age-related physical performance decline

Increasing understanding of the complex pathophysiology of this disease has led to considerable expansion of the MS therapeutic toolbox over the past 20 years, but substantial limitations remain

Hayes J, Mclellan L