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Class NSAID (preferential COX-2 inhibitor) Mechanism of action Inhibits cyclo-oxygenase (mainly COX-2) prostaglandin synthesis pain, inflammation, and swelling Indications Osteoarthritis Rheumatoid arthritis Ankylosing spondylitis Musculoskeletal pain Dental pain Post-operative pain Dysmenorrhea Dose (Adults) 100 mg orally twice daily Best taken after meals to reduce gastric irritation Advantages Better GI tolerability than some older NSAIDs (e.g