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The surge in cortisol is believed to be due to anticipation of the day ahead and an increased CAR is observed in individuals with perceived elevated burden e.g., unemployed individuals have higher CAR measurements when compared to employed individuals
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In contrast, it has been rarely explored how these metabolic intermediates are accurately sensed by cell cycle machinery to ensure that there is enough material to complete the transition between cell cycle phases
Mutations in the CYBA gene account for approximately 5% of CGD cases