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indicated that the number of Purkinje cells in the vermis of the cerebellum was 15 standard deviations below the mean and approximately 8 standard deviations below the mean bilaterally in the cerebral hemispheres of the individuals with autism compared with controls

74 The development of steatosis and the inhibition of proteasome activity, both hallmark signatures of alcohol-induced liver damage, occur as a result of the reduced SAM/SAH ratio

An aberration in EGFR causes over-activation of downstream proto-oncogenic signals such as Ras-Raf-ERK MAPK and Akt-PI3K-mTOR pathways, and is thereby frequently linked to the initiation and progression of hyperproliferative diseases such as cancer [358]

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Moreover, in some conditions there may be an ectopic production of thyroid hormones, leading to increased thyroid hormones and a compensatory decrease of TSH, Table 1 (Oo KM n.d

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