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Topical formulations (0.1-1%) have shown improvements in skin firmness, fine lines, and clarity in multiple cosmetic studies

Interestingly, many of the ADs associated with CD are also associated with RA including SLE, T1D, Sjgrens syndrome and multiple sclerosis (Hemminki et al

10.1111/nyas.15187 22 GrantB.KeanJ.ValiN.CampbellJ.MadenL.BijralP.et al (2023b)

SHR exhibit also a reduction of WM volume (413, 415) but it is unclear whether this is related to hypertension

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